The league leaders have been in impeccable form of late, and they brought their good mood to Stadio Giovanni Zini.
While they did not create chances in flurries, Gil Azzurri controlled the tempo and pinned their opponents deep into their own half.
Finally, they were given a chance to breakthrough when the man whose name is on everybody’s lips, Khvicha Kvaratskhelia, was taken down in the box after some superb footwork by Matteo Bianchetti.
After being awarded a penalty-kick thanks to a VAR check, Matteo Politano stepped up and dispatched from the spot to give the visitors a deserved lead at the break.
Though Napoli looked nearly untouchable at times, it took less than five minutes for Cremonese to equalise in the second period.
Much to the delight of the boisterous home crowd, Cyriel Dessers collected a deflected ball in the center of the box and stabbed home to level the scoreline.
While the game looked to be heading towards a stalemate, Serie A’s premier side so far this season showed their quality in the end.
With 15 minutes remaining in regular time, Simeone towered above the Cremonese defence to get on the end of a Mario Rui cross and head home a pivotal goal for Napoli.
To ensure they collected all three points, Hirving Lozano and Mathias Olivera both scored in stoppage time as Cremonese poured bodies forward, sending the travelling Napoli fans behind the goal into delirium.
Despite being largely outplayed, the Grigiorossi will be encouraged to run the league leaders all the way to the end of the game.
However, the Serie A newcomers remain winless in nine games and find themselves already staring down a potential trip back to Serie B if they do not pick up their form.
Flashscore Man of the Match: Matteo Politano (Napoli)