Riccardo Calafiori (22) will miss Italy's Nations League fixture against Israel with a calf injury, the country's football federation said on Sunday.
In a statement, the FIGC said that Calafiori would return to Arsenal after suffering a bruised left calf in Friday's impressive 3-1 win over France in Paris.
Calafiori was hurt in a freak accident when Ousmane Dembele was sent flying into his calf after being tackled by Alessandro Bastoni.
Italy, whose European Championship title defence ended in humiliating fashion in the last-16 this past summer, face Israel in Budapest on Monday night.
Luciano Spalletti's team are level on three points in Group A2 with Belgium, who beat Israel 3-1 on Friday.