Tennis Tracker: Djokovic made to work for straight-set victory
23:29 CET - Some unfortunate news for Dominic Thiem (29) fans as the Austrian player has had to retire from his match against Ben Shelton (20) through injury.
Elsewhere, Victoria Azarenka's (33) run at the US Open has come to an end after she was beaten by Lin Zhu (29) 6-3, 6-3.
22:51 CET - He may have had a great run at Wimbledon, but Chris Eubanks (27) has fallen early at his home slam after being beaten by Benjamin Bonzi (27) in four sets 7-6, 2-6, 6-2, 7-6.
22:01 CET - Novak Djokovic (36) was made to work by Bernabe Zapata Miralles (26), but the Serbian second seed came through the test in straight sets, beating the Spaniard 6-4, 6-1, 6-1 in just over two hours.
21:49 CET - From a big shock to something of very little surprise as world number one Iga Swiatek (21) has beaten Daria Saville (29) in straight sets, 6-3, 6-4 to advance into the third round at Flushing Meadows.
21:30 CET - A HUGE shock in the men's draw with Switzerland's Dominic Stricker (21) has beaten seventh seed Stefanos Tsitsipas (24) in five sets 7-5, 6-7, 6-7, 7-6, 6-3 after more than four hours of play. It was Stricker's first win over a top 10 player - what a time to do it!
21:20 CET - French Open finalist Karolina Muchova (27) has made light work of Magdalena Frech (25) in her second round match, winning their encounter 6-3, 6-3.
20:22 CET - Second seed Novak Djokovic (36) has started his match against Bernabe Zapata Miralles (26) on Arthur Ashe - make sure to follow the game live now.
19:37 CET - The first results are starting to tricke through from Flushing Meadows and its good news for the home fans with favourite Coco Gauff (19) strolling past teenage sensation Mirra Andreeva (16) 6-3, 6-2.
And we have our first shock of the day with 19th seed Brazillian Beatriz Haddad Maia (27) knocked out by American Taylor Townsend (27) in straight sets 7-6, 7-5.
17:18 CET - Play is about to get underway at the US Open, with Belinca Bencic (26) and Stefanos Tsitsipas (25) ready to begin. In action later today, we have Coco Gauff (19), Novak Djokovic (36) and Iga Swiatek (22), while Elena Rybakina (24) and Frances Tiafoe (25) take to the court during the night session.
8:02 CET - Jessica Pegula (29) may be the top-ranked American at the US Open but the third seed says she is happy to let red-hot compatriot Coco Gauff (19) carry some of the burden of expectation as they bid to end the country's Grand Slam drought.
World number three Pegula and number six Gauff arrived in New York having won WTA 1000 titles to spark hopes of a first American women's major champion since Sofia Kenin lifted the trophy at the 2020 Australian Open.
Pegula cruised to a 6-2, 6-2, opening win over Camila Giorgi on Tuesday - a day after Gauff rallied to beat Laura Siegemund - and the experienced American said that she did not mind the focus being on her frequent doubles partner at the tournament.
7:41 CET - Andy Murray (36) will have his family with him to celebrate his 200th Grand Slam match win on Tuesday, as the Briton joined rare company with a straight-sets defeat of France's Corentin Moutet (24) in the US Open first round.
The veteran is only the ninth man to earn 200 match wins in major competition, despite an abdominal injury that cut short his North American hardcourt campaign ahead of the year's final major.
7:30 CET - Former US Open champion Stan Wawrinka (38) said he still had the game for the grandest stage after the Swiss veteran became the oldest man to win a singles contest at the tournament since a 40-year-old Jimmy Connors in 1992.
Wawrinka, who claimed the last of his three Grand Slam titles at New York in 2016, rolled back the years to outclass Japan's Yoshihito Nishioka 7-6(5), 6-2, 6-4, moving with ease despite foot issues that have plagued him in recent years.
5:45 CET - 2022 US Open champion Carlos Alcaraz didn't struggle to move through to the second round as his opponent Dominik Koepfer was forced to retire due to injury in the second set as the match ended 6-2, 3-2.
World number six Jannik Sinner was also victorious as he defeated Yannick Hanfmann 6-3, 6-1, 6-1.
It took Hubert Hurkacz over three hours and five sets to get past Marc-Andrea Huesler as the Pole won with 4-6, 5-7, 7-6, 6-3, 6-1.
Later on in the day we'll see world number two Novak Djokovic looking for his 24th Grand Slam title clashing with Bernabe Zapata Miralles, Stefanos Tsitsipas taking on Dominic Stricker and Casper Ruud wrapping up the day with his match against Zhizhen Zhang.
Meanwhile, Aryna Sabalenka eased past Maryna Zanevska 6-3, 6-2 to progress to the second round.
Venus Williams left the competition early on as she lost to Greet Minnen 6-1, 6-1.
A clash of talented teenagers takes place in the evening as Coco Gauff and Mirra Andreeva meet, and current champion Iga Swiatek faces Daria Saville.